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Which is better magnesium citrate or glycinate? A comprehensive comparison

5 min read

According to the National Institutes of Health, a significant portion of the U.S. population does not meet the recommended daily intake for magnesium, leading many to consider supplements. When choosing a supplement, knowing which is better magnesium citrate or glycinate depends entirely on your specific health goals.

Quick Summary

This guide differentiates between two popular magnesium forms, explaining their distinct properties and primary uses. It highlights magnesium citrate's effectiveness for digestive health and magnesium glycinate's benefits for relaxation and sleep. The article also covers absorption, potential side effects, and helps determine the right choice for individual needs.

Key Points

  • Purpose-Driven Choice: Choose magnesium citrate for occasional constipation relief and magnesium glycinate for relaxation, anxiety, and sleep support.

  • Different Mechanisms: Citrate works as a laxative by drawing water into the intestines, while glycinate provides calming effects with its glycine component.

  • Consider Side Effects: Magnesium citrate can cause digestive upset and diarrhea, whereas magnesium glycinate is much gentler on the stomach.

  • Bioavailability Factors: Both forms are well-absorbed, but glycinate's chelated structure ensures consistent absorption without causing digestive issues.

  • Consult a Professional: Always talk to a healthcare provider before starting a new supplement, especially if you have existing health conditions or take other medications.

  • Assess Tolerance: If you have a sensitive stomach, magnesium glycinate is the more tolerable option for long-term supplementation.

In This Article

Understanding the Different Forms of Magnesium

Magnesium is an essential mineral involved in over 300 biochemical reactions in the body, playing a crucial role in nerve function, muscle contraction, blood pressure regulation, and energy production. While a healthy diet provides magnesium from sources like leafy greens, nuts, and seeds, supplements are often used to bridge nutritional gaps. Not all magnesium supplements are created equal, and the form of magnesium significantly impacts its intended use, absorption (bioavailability), and potential side effects. Magnesium citrate and magnesium glycinate are two of the most common and bioavailable forms available on the market, yet they serve different primary functions.

Magnesium Citrate: The Digestive Aid

Magnesium citrate is a combination of magnesium and citric acid. This compound dissolves readily in water and acts as an osmotic laxative, meaning it draws water into the intestines. This action helps to soften stool and promote bowel regularity, making it highly effective for treating occasional constipation.

Primary uses for magnesium citrate:

  • Relief from Occasional Constipation: This is its most common and well-known use. It is a powerful, fast-acting saline laxative, often used for bowel preparation before medical procedures like colonoscopies.
  • Correcting Magnesium Deficiency: Due to its relatively high bioavailability, magnesium citrate can also be an effective option for those needing to restore overall magnesium levels.
  • Electrolyte Replenishment: After strenuous exercise, it can help replenish electrolytes lost through sweat.

Potential Side Effects of Magnesium Citrate

The osmotic effect that makes magnesium citrate an effective laxative can also lead to side effects, especially at higher doses. These can include:

  • Diarrhea
  • Abdominal cramping
  • Nausea
  • Bloating

Magnesium Glycinate: The Calming Companion

Magnesium glycinate is formed by combining magnesium with the amino acid glycine. This chelated structure makes it gentle on the stomach and highly absorbable, without the potent laxative effect associated with magnesium citrate. The added glycine, an inhibitory neurotransmitter, also provides calming effects that benefit the nervous system.

Primary uses for magnesium glycinate:

  • Anxiety and Stress Reduction: The combination of magnesium's nervous system regulation and glycine's calming properties can help reduce stress and anxiety levels.
  • Improved Sleep Quality: Magnesium glycinate may aid in promoting relaxation, quieting the mind, and enhancing overall sleep quality, making it a popular choice for nighttime use.
  • Muscle Relaxation: It helps relax muscles and can be effective for relieving muscle cramps, tension, and spasms, without the digestive upset of other forms.
  • Long-Term Supplementation: Its superior tolerability makes it an ideal option for those seeking long-term, gentle magnesium support.

Potential Side Effects of Magnesium Glycinate

Magnesium glycinate is generally well-tolerated, even at higher doses. Side effects are rare but can occur with excessive intake and may include:

  • Drowsiness
  • Nausea
  • Fatigue

Magnesium Citrate vs. Glycinate: A Detailed Comparison

Feature Magnesium Citrate Magnesium Glycinate
Primary Use Occasional constipation, bowel prep, general deficiency correction Anxiety, sleep support, stress reduction, muscle relaxation
Mechanism Draws water into the intestines (osmotic effect) to stimulate bowel movements Chelated with glycine, which is highly bioavailable and has calming effects on the nervous system
Bioavailability High, but can be influenced by dosage due to its laxative nature High, and generally more consistently absorbed with fewer digestive issues
Side Effects Often causes loose stools, cramping, and digestive upset at laxative doses Very gentle on the stomach; minimal gastrointestinal side effects
Ideal for Short-term constipation relief, correcting significant deficiency Long-term daily supplementation, managing anxiety or sleep disturbances

Which Should You Choose?

The decision of which is better magnesium citrate or glycinate is determined by your primary health goal. For digestive regularity, citrate is the clear choice, while for calming effects and better sleep, glycinate is the superior option.

For Constipation Relief

If your main purpose is to relieve occasional constipation, magnesium citrate is the more effective form due to its potent laxative properties. However, it should not be used long-term for chronic constipation without consulting a healthcare provider, as it can cause fluid and electrolyte imbalances.

For Sleep and Relaxation

If you are looking to improve sleep, reduce anxiety, or manage stress, magnesium glycinate is the better option. Its combination with glycine enhances its calming effects on the nervous system and makes it gentle enough for nightly use without the risk of digestive side effects.

For General Supplementation and Deficiency

For general supplementation to correct a magnesium deficiency, both forms are excellent due to their high bioavailability. If you have a sensitive stomach or want to avoid any potential digestive upset, magnesium glycinate is the safer, more tolerable choice for long-term daily use.

Can You Take Both?

Yes, it is possible and potentially beneficial to take both, depending on your needs. A common approach is to use magnesium citrate earlier in the day for digestive support, and magnesium glycinate in the evening to promote relaxation and sleep. Always be mindful of your total daily intake and consult a healthcare professional to determine the right dosages.

Choosing a High-Quality Supplement

Regardless of which form you choose, selecting a high-quality product is essential. Look for supplements that have been independently tested and certified by organizations such as NSF International, USP (United States Pharmacopeia), or ConsumerLab. These certifications help ensure the product contains the ingredients listed on the label and is free of harmful contaminants.

Conclusion

Understanding the distinct actions of magnesium citrate and magnesium glycinate is key to making an informed supplement choice. While magnesium citrate is a potent and fast-acting option for occasional constipation and restoring levels, its laxative effect is not suitable for everyone, particularly those seeking relaxation. Magnesium glycinate, on the other hand, is the gentler alternative, prized for its calming benefits on the nervous system and ability to support sleep, stress reduction, and muscle relaxation. Ultimately, the superior option depends on your specific health concerns, and for many, the targeted benefits of glycinate make it the preferred choice for regular supplementation. Always consult with a healthcare professional to discuss your individual needs before starting a new supplement regimen.


Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any new supplement regimen.

MedlinePlus: Magnesium Citrate

Frequently Asked Questions

The main difference is their primary effect. Magnesium citrate is a saline laxative used for constipation, while magnesium glycinate is known for its calming properties and is used to aid sleep and reduce anxiety.

Magnesium glycinate is generally considered better for sleep. It is combined with the amino acid glycine, which has calming effects on the nervous system, helping to promote relaxation and improve sleep quality.

Magnesium glycinate is often recommended for anxiety. Its high bioavailability and the added calming effects of glycine help to regulate neurotransmitters, promoting a sense of calm and well-being.

Yes, you can take both, but they have different purposes. Some people take magnesium citrate in the morning for digestive support and magnesium glycinate at night for sleep and relaxation.

Yes, magnesium citrate works as an osmotic laxative, drawing water into the intestines to soften stool and stimulate bowel movements. It is a powerful and fast-acting laxative.

Yes, magnesium glycinate is significantly gentler on the stomach than magnesium citrate. Its chelated form is well-tolerated and less likely to cause digestive side effects like diarrhea or cramping.

The time it takes to feel the effects of magnesium glycinate can vary. Some people notice a difference in a few days, while others may take a few weeks to experience improved sleep quality.

Individuals with kidney disease or those with a sensitive digestive system should be cautious with magnesium citrate due to its strong laxative effect and potential for electrolyte imbalance. Always consult a doctor before use.

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.