The Science Behind Colief: Lactase and Lactose Digestion
Colief's mechanism of action centers on lactase, an enzyme produced in the small intestine to break down lactose, the sugar found in milk. For some newborns, a temporary deficiency in lactase means they struggle to digest lactose effectively. Undigested lactose ferments in the large intestine, leading to gas, bloating, and discomfort often associated with colic. Colief Infant Drops contain lactase, which, when added to milk before feeding, helps break down lactose externally, reducing the amount reaching the baby's digestive system and thereby alleviating colic symptoms caused by temporary lactose intolerance.
How to Administer Colief Drops
The method for administering Colief depends on the feeding method. The drops are added to warm milk, allowing time for the enzyme to act.
Administration for Breastfeeding
Add four drops of Colief to a small amount of expressed breast milk in a sterilized container and give it to the baby before breastfeeding as usual.
Administration for Formula Feeding (Standard Method)
Prepare formula, let it cool, add four drops of Colief, wait 30 minutes while shaking occasionally, then feed the baby. Discard any unused formula.
Administration for Formula Feeding (In-Advance Method)
Prepare formula, let it cool, add two drops of Colief, refrigerate for at least four hours, then warm to feeding temperature. This method is suitable for preparing feeds in advance.
Colief vs. Other Colic Remedies
Various colic remedies exist, each with a different approach. Colief specifically targets temporary lactose intolerance, while others address different aspects of digestive discomfort.
| Feature | Colief Infant Drops | Gas Drops (e.g., Simethicone) | Gripe Water | Herbal Colic Remedies |
|---|---|---|---|---|
| Mechanism | Contains lactase enzyme to break down lactose before digestion. | Contains simethicone, an anti-foaming agent that breaks down gas bubbles in the stomach. | Varies by brand but often contains a mixture of herbs like fennel, ginger, or chamomile. | Often herbal blends with varying ingredients, claiming to soothe or calm. |
| Target Issue | Addresses temporary lactose intolerance, which causes gas and discomfort. | Addresses trapped wind and gas bubbles directly in the stomach. | Aims to settle stomach upset and ease indigestion. | Provides a general soothing effect for digestive discomfort. |
| How to Use | Added to milk before feeding, requires a waiting period. | Can be given directly to the baby during or after a feeding. | Typically given directly to the baby via a dropper or syringe. | Dosage and timing vary by brand and ingredients. |
| Main Ingredient | Lactase enzyme, glycerol, and water. | Simethicone. | May contain sodium bicarbonate and various herbs. | Plant-based extracts. |
Clinical Evidence and Development
Clinical studies, including research at Cork University Hospital and Guy's Hospital, have shown that using lactase enzymes to treat milk can reduce symptoms of infantile colic. Further studies in China have demonstrated Colief's safety and effectiveness in improving lactose intolerance symptoms in premature infants.
Conclusion: A Targeted Solution for Temporary Lactose Intolerance
Colief offers a targeted approach to infant colic by addressing temporary lactose intolerance. The lactase enzyme in the drops helps pre-digest lactose, preventing the gas and pain associated with undigested sugar. Supported by clinical evidence, Colief can provide relief and contribute to a more settled feeding experience.
Frequently Asked Questions
Q: How long does Colief take to work?
A: When added to formula, Colief requires a 30-minute wait period to break down lactose effectively. Some parents notice an improvement within a few days, while others may take up to a week to see significant changes. For breastfeeding, the enzyme works quickly after mixing with expressed foremilk.
Q: What are the side effects of Colief?
A: Colief is generally well-tolerated. A common side effect is a change in stool pattern, which may become looser and more frequent. Reducing the dosage may help if this occurs. Consult a healthcare professional with any concerns.
Q: Can Colief be used for both breastfed and formula-fed babies?
A: Yes, Colief is suitable for use with both breast milk and infant formula, with specific instructions for each.
Q: Does Colief contain any allergens?
A: The lactase in Colief is derived from yeast and is generally gluten-free. Always check the label for ingredients.
Q: How is Colief different from gripe water or simethicone gas drops?
A: Colief uses an enzyme to prevent gas by breaking down lactose, while simethicone breaks up existing gas bubbles. Gripe water typically contains herbs to soothe discomfort. Colief targets temporary lactose intolerance.
Q: How long can a baby use Colief drops?
A: Most babies develop sufficient lactase by three to four months, at which point symptoms often disappear, and Colief can be withdrawn. It can be used for as long as needed if symptoms persist.
Q: What happens if I forget to wait 30 minutes after adding Colief to formula?
A: According to the manufacturer, Colief will still work but may be less effective. The waiting period allows for maximum lactose breakdown.
Q: Can I prepare multiple bottles of formula with Colief at once?
A: Yes, using the in-advance method, bottles with two drops of Colief can be prepared and refrigerated for a minimum of 4 hours and used within 12 hours.
Q: Does the temperature of the milk matter when using Colief?
A: Yes, Colief is most effective in warm milk (body temperature). Avoid hot or cold milk.
Q: Where can I find more information about the clinical trials on Colief?
A: Information on clinical studies can be found on the manufacturer's website and in publications such as the Journal of Human Nutrition and Dietetics and the Journal of Clinical Pediatrics.
