The Link Between Colic and Lactose
Infant colic is often characterized by prolonged, unexplained crying in an otherwise healthy newborn. While the exact cause can vary, one contributing factor is a temporary lactose intolerance. Lactose is a complex sugar naturally present in both breast milk and infant formula. To digest this sugar, the body requires an enzyme called lactase, which is produced in the small intestine. For some infants, their digestive system is still developing and may not produce enough lactase. This temporary deficiency means that undigested lactose can ferment in the gut, leading to gas, bloating, and discomfort commonly associated with colic.
The Pharmacology of Colief Infant Drops
Colief Infant Drops are designed to counteract this temporary lactase deficiency. The drops contain the lactase enzyme itself, which is a natural, safe ingredient derived from a non-dairy source. When added to a baby's milk (either formula or expressed breast milk) before a feed, the enzyme goes to work outside of the baby's body. This is a key distinction from other colic products, like simeticone, which acts on existing gas bubbles inside the baby's stomach. Colief's mechanism is to pre-digest the milk, reducing the lactose content before the baby consumes it.
The Importance of the 30-Minute Waiting Period
The 30-minute waiting period is crucial for the lactase enzyme to be effective. This isn't a suggestion; it's a core part of the product's pharmacology. The process is as follows:
- Enzyme Action: The lactase enzyme in Colief needs time to chemically react with the lactose in the milk. This process is known as hydrolysis, where the lactase breaks down the complex lactose molecule into two simpler, more easily digestible sugars: glucose and galactose.
- Optimal Breakdown: Laboratory trials have demonstrated that a 30-minute wait time, with the milk at body temperature, is necessary to break down a significant amount of the lactose. Feeding the milk sooner will result in less lactose being broken down, and therefore a less effective outcome.
- Gentler Digestion: By the time the baby drinks the pre-digested milk, a significant portion of the lactose is already broken down. This reduces the amount of lactose that would otherwise cause gas and discomfort in their immature digestive system.
Comparison of Feeding Methods with Colief
| Feature | Colief with Bottle (Formula or Expressed Milk) | Colief with Breastfeeding | Colief with Advanced Refrigerated Formula |
|---|---|---|---|
| Waiting Time | 30 minutes at body temperature | No wait time; given just before feeding | Minimum 4 hours in the refrigerator |
| Application | The drops are added to warm milk in a bottle and require a waiting period | The drops are added to a spoonful of expressed foremilk and given to baby | The drops are added to prepared formula and refrigerated for a period |
| Mechanism | The lactase enzyme pre-digests the lactose in the bottle. | The enzyme is given orally, where it is retained in the upper digestive tract and acts on lactose as the baby feeds. | The enzyme slowly pre-digests the lactose while stored in the cold. |
| Ideal Temperature | Optimal at body temperature for efficient enzyme activity. | The enzyme is protected by the milk and works at body temperature as baby feeds. | Low temperature slows the enzyme, requiring more time to act. |
Adjusting the Waiting Time and Discontinuing Use
As an infant's digestive system matures, usually between three and four months of age, they may start producing enough lactase on their own. The manufacturer suggests that after the first month, parents can try a shorter wait time to see if it is still effective. If symptoms return, revert to the initial period. Eventually, you can gradually reduce the use of Colief until it is no longer needed. This phased approach helps ensure a smooth transition for the baby.
Conclusion
In summary, the pharmacology of Colief requires a specific period of time for the lactase enzyme to break down the lactose in milk outside of a baby's digestive system. The mandatory waiting period isn't a nuisance but an essential step that ensures the medication can effectively reduce the level of lactose before feeding, thereby alleviating the symptoms of temporary lactose intolerance. By adhering to the recommended instructions, parents can maximize the benefits of Colief and help their little ones find relief from colic. It is always wise to consult with a healthcare professional before starting any new medication or supplement regimen for an infant, ensuring that the treatment aligns with their specific needs.
Frequently Asked Questions
Q: Why do you have to wait 30 minutes with Colief? A: You must wait 30 minutes to allow the lactase enzyme in Colief to effectively break down the lactose in the milk before you give it to your baby. This pre-digestion process makes the milk easier to digest and reduces colic symptoms.
Q: What happens if I don't wait 30 minutes after adding Colief? A: If you don't wait the full 30 minutes, the lactase enzyme will not have enough time to break down a sufficient amount of lactose, making the treatment less effective.
Q: How does Colief work for breastfeeding babies? A: For breastfeeding, you mix Colief with a few tablespoons of expressed foremilk and give it to the baby on a spoon before feeding. A 30-minute wait is not required because the enzyme acts in the baby's upper digestive tract as they feed.
Q: Can I prepare bottles with Colief in advance? A: Yes, you can prepare bottles in advance. Add Colief to the formula and store in the refrigerator for at least 4 hours. Keep in mind that the cooler temperature slows the enzyme, requiring a longer wait time.
Q: Is it okay to use Colief if my baby does not have lactose intolerance? A: Colief is a supplement containing a naturally occurring enzyme. While generally safe, it's intended for babies with symptoms of temporary lactose intolerance. It's best to consult a healthcare professional to confirm the cause of your baby's colic before using the product.
Q: How long should I continue using Colief for my baby? A: Most babies' digestive systems mature by around three to four months, and symptoms naturally disappear. At this point, you can gradually reduce the use of Colief to see if it's still needed.
Q: Does temperature affect how long Colief takes to work? A: Yes, temperature affects the enzyme's activity. At body temperature, it works faster, requiring 30 minutes. When refrigerated, the enzyme's activity is slower, so a longer wait time of at least 4 hours is needed.
