Skip to content

What are the side effects of anesthesia spray?

4 min read

According to the U.S. Food and Drug Administration (FDA), the use of benzocaine-containing anesthesia spray has been linked to a rare, but serious blood condition called methemoglobinemia, which can reduce the amount of oxygen in the bloodstream. While most side effects of anesthesia spray are mild and localized, it is crucial to understand both the common and potentially severe reactions associated with topical anesthetics, such as lidocaine and benzocaine.

Quick Summary

Anesthesia sprays can cause common side effects like mild skin irritation, stinging, or redness at the application site. Serious but rare risks include life-threatening methemoglobinemia, cardiovascular issues, and severe allergic reactions. The severity and type of side effects vary by active ingredient, concentration, application, and individual patient health, emphasizing the need for safe usage and medical guidance.

Key Points

  • Common Side Effects: Mild, localized reactions include temporary burning, stinging, redness, and itching at the application site.

  • Oral Application Risks: When used in the mouth, sprays can cause temporary swallowing difficulties and increase the risk of accidentally biting your tongue or cheek.

  • Methemoglobinemia (Benzocaine): Rare but serious, this blood disorder can be caused by benzocaine and leads to dangerously low oxygen levels, especially in children under two.

  • Local Anesthetic Systemic Toxicity (LAST): A rare, life-threatening complication affecting the nervous system and heart, potentially causing seizures or arrhythmias, often from overuse.

  • Severe Allergic Reactions: Though rare, symptoms like hives, swelling of the face or throat, and difficulty breathing require immediate medical attention.

  • Safe Usage Protocol: Always follow dosing instructions, avoid using on large or broken skin, prevent inhalation, and monitor for any unusual symptoms.

In This Article

Understanding Anesthesia Sprays and Their Ingredients

Anesthesia sprays are topical medications used to numb a specific area of the body to relieve pain or prepare for a minor medical procedure. The two most common active ingredients are lidocaine and benzocaine, each with a distinct profile of potential side effects. While generally safe when used correctly, overuse or improper application can lead to complications ranging from minor skin reactions to serious systemic issues.

Common Side Effects

Most users of anesthesia sprays will only experience localized, temporary side effects that resolve on their own. These common reactions are usually mild and not a cause for serious concern unless they persist or worsen.

Common Topical Reactions

  • Burning or stinging: A temporary sensation at the application site immediately after spraying.
  • Redness or irritation: Mild erythema (redness) is common where the spray is applied.
  • Itching or dry skin: Some individuals may experience localized itching or dry, scaly skin.
  • Numbness beyond the application site: Accidental spraying can cause temporary numbness in unintended areas.

Application-Specific Effects

  • Oral and throat numbness: When used in the mouth or throat, the spray can impair the ability to swallow or taste normally for a short time. This can increase the risk of accidentally biting the tongue or cheek.
  • Inhalation irritation: Inhaling the aerosol can cause a sore throat or irritation in the nose.

Serious but Rare Side Effects

While uncommon, certain serious side effects require immediate medical attention. These can affect the central nervous system and cardiovascular system or cause severe allergic reactions, often due to excessive use, improper application, or pre-existing medical conditions.

Methemoglobinemia

This is a rare but potentially fatal blood disorder associated with benzocaine sprays, especially in infants and individuals with certain health conditions. It occurs when the hemoglobin in red blood cells is oxidized, preventing it from carrying oxygen effectively.

Symptoms of Methemoglobinemia include:

  • Pale, gray, or blue-colored skin, lips, and nail beds.
  • Headache and lightheadedness.
  • Shortness of breath.
  • Unusual fatigue or weakness.
  • Rapid heart rate.

Local Anesthetic Systemic Toxicity (LAST)

LAST is a rare, life-threatening complication that can affect the central nervous system and cardiovascular system. It can occur when a local anesthetic is absorbed into the bloodstream too quickly or in high doses.

Early signs of LAST can include:

  • Numbness around the mouth or a metallic taste.
  • Auditory changes, such as ringing in the ears (tinnitus).
  • Dizziness or blurred vision.
  • Confusion, anxiety, or tremors.

Advanced symptoms of LAST can include:

  • Seizures.
  • Irregular heart rhythm (arrhythmias) or a slowed heart rate.
  • Low blood pressure.
  • Cardiac arrest in severe cases.

Severe Allergic Reactions

Although true allergic reactions to local anesthetics are rare, they can happen and may be serious.

Signs of a severe allergic reaction include:

  • Hives or a spreading skin rash.
  • Swelling of the face, lips, tongue, or throat.
  • Difficulty breathing or chest tightness.

Comparison of Lidocaine and Benzocaine Sprays

Understanding the differences between the two most common types of anesthesia sprays can help you and your healthcare provider make an informed decision.

Feature Lidocaine-Based Sprays Benzocaine-Based Sprays
Onset of Action Provides relatively quick and reliable pain relief. Very fast-acting for immediate relief of minor irritations.
Primary Use Often used for medical procedures, dental treatments, or longer-lasting pain relief. Common in over-the-counter products for temporary relief of minor mouth sores or skin irritations.
Methemoglobinemia Risk While possible, it is more commonly associated with benzocaine products. Higher risk, especially with overuse, in young children, or in patients with certain conditions.
Application Considerations Must be used carefully on mucous membranes to avoid swallowing impairment. Flammable contents; must be kept away from heat and flame.

Precautions and Safe Use

To minimize the risk of side effects, it is crucial to follow product instructions and take appropriate precautions.

Always follow these guidelines:

  • Use as directed: Apply only the smallest amount needed and never use more often than recommended.
  • Avoid large areas: Do not use topical sprays over large areas of the body, or on broken, irritated, or swollen skin.
  • Prevent inhalation: Avoid spraying directly on the face and ensure adequate ventilation to prevent inhalation.
  • Wait to eat or drink: After using oral anesthesia spray, wait at least one hour before eating or drinking to prevent accidentally biting the numb tissue or choking.
  • Consult a professional: Talk to a healthcare provider before using a new product, especially if you have pre-existing health conditions or are on other medications.
  • Monitor for symptoms: Be vigilant for any signs of methemoglobinemia, LAST, or severe allergic reactions.

Conclusion

While anesthesia sprays are effective tools for temporary pain relief, they are not without risk. Most side effects are minor and confined to the application site. However, the rare but serious complications, such as methemoglobinemia and local anesthetic systemic toxicity, underscore the importance of correct usage and careful monitoring. By understanding the potential side effects, following application guidelines, and consulting with a healthcare professional when necessary, individuals can minimize risks and use these products safely.

For more detailed information on anesthetic toxicity management, consider resources like Medscape.

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Consult a healthcare professional for diagnosis and treatment.

Frequently Asked Questions

Methemoglobinemia is a rare but life-threatening blood disorder, most commonly associated with benzocaine-containing anesthesia sprays, where the red blood cells lose their ability to carry oxygen effectively. Symptoms include pale, gray, or blue skin, headache, fatigue, and rapid heart rate.

Yes, some anesthesia sprays are formulated for oral use to numb a sore throat. However, you must use it as directed and be aware of temporary numbness that can affect your ability to swallow or taste, which can increase the risk of accidentally biting your tongue.

Symptoms of an allergic reaction include skin rash, hives, swelling of the face, lips, tongue, or throat, and difficulty breathing. A severe reaction (anaphylaxis) is a medical emergency requiring immediate attention.

While many side effects overlap, benzocaine-based sprays carry a higher risk of causing methemoglobinemia compared to lidocaine sprays, especially with overuse or in vulnerable populations like infants. Lidocaine is often used for longer-lasting pain relief.

If you suspect an overdose or experience severe symptoms like dizziness, confusion, or vision problems, seek emergency medical help immediately. Overuse can lead to serious systemic toxicity.

No, the FDA strongly warns against using benzocaine-based products for teething in children under two years old due to the risk of methemoglobinemia. It is recommended to use alternative methods like a chilled teething ring and consult a pediatrician.

Always follow the product directions, avoid using on broken or large skin areas, do not inhale the spray, and keep away from heat or open flames as contents can be flammable. Also, wait at least an hour to eat or drink after oral application.

References

  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  6. 6
  7. 7
  8. 8

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.